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Clinical and experimental evidence indicate that PD-1 inhibition can restore effective immune responses in chronic infections and cancers, highlighting its therapeutic potential

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Dysfunction of the MD thalamus, a primary node within a thalamic-PFC-basal ganglia network involved in associative learning, is implicated in the transition from goal-directed action (e.g., recreational drug use) to habitual forms of responding (e.g., dysregulated drug seeking) [83, 84]

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