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Note that 2-PAM has an affinity for the acetylcholine anionic binding site on cholinesterase (right middle panel), which could explain the oxime related worsening of cholinergic side effects when 2-PAM is administered prior to the onset of action of atropine in the setting of organophosphate poisoning, by transiently preventing nerve-agent free cholinesterase from interacting with acetylcholine

The results were analyzed by FlowJo 7.6.2 software (Tree Star Inc., Ashland, OR, USA)

American ginseng possesses adaptogenic and anti-inflammatory properties (Jia 2009

The relative cellular MDA concentration was presented as a percentage of control after normalized to protein contents