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A study of hypothyroid patients found that probiotic supplements reduced the need for thyroid medication and reduced fatigue [12]

(PubMed) Du XH, Dai XX, Xia Song R, et al

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These mechanisms include decreased expression of proteins that are key to mPTP formation, such as voltage-dependent anion channel (VDAC) and cyclophilin D (Cyp-D) [128], and the increased levels of nuclear factor erythroid-2 related factor 2 (Nrf2) [128], a transcription factor that is activated under stress conditions regulating the expression of antioxidant, anti-inflammatory, and detoxification enzymes that prevent mitochondrial impairment [131]

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