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Data availability The IMAGEN project data are available from a dedicated database: ABCD data are available from a dedicated database: HCP data are available from a dedicated database: All data needed to evaluate the conclusions in this study are present in the paper and/or the Supplementary Information

Smoking is linked to severe, preventable diseases

Cigarette smoke not only causes harm to yourself and those around you, it can also harm and cause damage to your HVAC system which could lead to potential breakdowns and expensive repairs

Chronic inflammation: a common and important factor in the pathogenesis of neoplasia

Philip Morris International Inc., Imperial Brands PLC, Japan Tobacco Inc., British American Tobacco PLC, and Juul Labs Inc