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Pregnancy and lactation: Avoid use during pregnancy or breastfeeding unless controlled human data show safety

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GPX4 is a GSH-dependent enzyme that can convert reduced glutathione to oxidized glutathione (GSSG) and reduce lipid hydroperoxide (L-OOH) to lipid alcohol (L-OH) to protect against lipid peroxidation

The second barrier to an amylin-analog drug was to extend the half-life relative to the first-generation drug, pramlintide, which is injected 3 times daily

Urate-lowering medicines are not indicated in people with hyperuricaemia who are asymptomatic