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doi: 10.1016/j.brainres.2011.12.028 [DOI] [PubMed] [Google Scholar] 45.Suzuki H, Miki S, Oshima M, Sado T

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Long-term HFD consumption increased hepatic IKK- glutathionylation and NF-B suppression The mechanistic investigations in our cell culture studies provided evidence suggesting that intracellular GSSG accumulation sensitizes hepatocytes to TNF cytotoxicity via the induction of IKK- glutathionylation, leading to reduced IKK- phosphorylation and subsequent NF-B suppression

Intracellular GSH levels regulate lymphocyte proliferation, T-cell activation, NK cell cytotoxicity, and macrophage function [7][8]