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Unfortunately, the small sample size and the lack of thyroid function data of enrolled patients prevent drawing conclusions on this possible effect

10.1016/B978-0-444-63849-6.00007-4 Handb

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The single published case series showing symptomatic improvement following intra-articular BPC-157 injection for knee pain provides preliminary support for this indication, though the small sample size, retrospective design, and lack of imaging or biomarker assessment limit conclusions

The body perceives the injury as a form of trauma and sends additional melanin to the site, resulting in darker patches that persist even after the original wound or irritation has healed