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The cycle of using more to feel the same effect increases the risk of addiction

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Whilst the physical dangers of smoking are well documented, from lung cancer to heart disease, a growing body of research reveals an equally troubling connection between cigarettes and mental wellbeing

some missense variants, especially within the collagenous domain of the protein, and a few intragenic rearrangements including (multi) exon deletions/duplications are also described [6, 7]