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There have been very limited reports of ipamorelin causing even such minor side effects

The effect was abolished by a PI3K inhibitor placing the mechanism on PI3K/AKT

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The Cystine/Glutamate antiporter, SLC7A11/xCT, mediates the uptake of extracellular cystine, which is reduced to cysteine, the precursor for glutathione synthesis, protecting cells from oxidative stress [6]