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Phase 4: Traction Therapy Mechanical Remodeling On the same evening following first injection session, patients begin daily PTT with the RestoreX TM device (PathRight Medical, USA) for a total duration of 90 minutes, consisting of sequential straight traction (15 min) followed by progressive counter-bending at 30 (15 min), 60 (15 min), and 90 (45 min), to optimize mechanotransductive remodeling while preserving treatment tolerability

99,287 Furthermore, elevated uric acid levels have been implicated in causing inflammation in endothelial cells via the activation of the receptor for advanced glycation end products (RAGE) signaling pathway

SC, subcutaneous