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Numerous studies suggest that phytochemicals in cruciferous vegetables are responsible for their chemoprotective effects, and among them, the glucosinolate breakdown products, isothiocyanates (ITC), are believed to be responsible for this anti-carcinogenic action (Table 1) ( Reference Holst and Williamson 6 )

13,14 In contrast, although our study showed that patients who had immune-related adverse events received a significantly higher median number of checkpoint inhibitor doses compared with patients without such adverse events, the number of checkpoint inhibitor doses received did not significantly predict the occurrence of immune-related adverse events

This study innovatively focuses on the mechanism by which FOXO4-DRI induces apoptosis in senescent endothelial cells, demonstrating that it functions by activating the p53/BCL-2/Caspase-3 signaling pathway to promote selective apoptosis of these cells

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