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Deficiency of tetrahydrobiopterin, an essential cofactor for eNOS, has been shown to promote eNOS unpairing, which attenuates NO production and tends to enhance ROS production [75]

According to the amended NICE guidelines, an individualised approach is more appropriate for ME/CFS patients ( Nutraceuticals and pharmacological approaches Many ME/CFS patients take nutritional supplements (530)

Sikiric et al., 2018), it should be noted that Roberts cytoprotection generally holds a defensive response against direct injuries

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