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In fact, one study showed that smokers taking statin drugs had an 86% increase in the risk of having a major cardiovascular event such as a heart attack, stroke, or death compared with nonsmokers on statins

Indigenous peoples were also known to offer tobacco as a gift or use it like currency and/or as a trade item

1 2 The American Journal on Addictions

Farmers and workers apply pesticides and growth regulators to tobacco plants at various points in the season (see below for detailed information on pesticides used in tobacco farming)

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