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Our exploratory analyses suggest that the combination of inserts and PHWLs produces a greater impact on the outcomes tested than either intervention alone, consistent with theory and empirical evidence 19-21

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For example, the elevated levels of TNF- after 20 weeks smoking was back to baseline levels after 8 weeks smoking cessation in the broncho-alveolar lavage fluid of mice 33 and similarly 30 days smoking cessation resulted in a significant reduction in TNF- in humans 28

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