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A survey from 2013 conducted by the International Institute of Population Sciences in collaboration with the ministry of health and family welfare found that Kolkata records the highest smoking rate in the country, with 56.6% of its population identified as smokers

The suppressive subpopulations contained both resting CD25 ++ CD45RA + Tregs (rTregs) and activated CD25 +++ CD45RA Tregs (aTregs) while the pro-inflammatory subpopulations were cytokine-secreting CD25 ++ CD45RA (FrIII) cells [68]

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Rampertab SD, Pooran N, Brar P, Singh P, Green PH: Trends in the presentation of celiac disease

Importantly, differential DNA methylation patterns identified in lung tissues from COPD patients have been linked to disturbed gene expression profiles, indicating a biologically relevant function of those CpG positions [18, 19]