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Metformin may result in suboptimal oral vitamin B12 absorption by competitively blocking the calcium-dependent binding of the intrinsic factor-vitamin B12 complex to its receptor

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It is recommended that adults over the age of 50 increase their sources of vitamin B12 through diet, fortified foods, B12 shots, or other supplements that can increase their B12 consumption. (By The National Institutes of Health) GASTROINTESTINAL ISSUES AND B12 SHOTS Persons who have gastrointestinal issues are particularly predisposed to issues with B12 deficiencies