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The halflife of nicotine and COHb are 3060 min and 46 h, respectively.[6] However, to reduce the volume of sputum production, smoking cessation of at least for 12 weeks is needed.[6] Abstinence of at least 34 weeks is needed to reduce complications related to wound healing.[7] Most investigators suggest that stopping smoking 2 months before surgery provides the maximum benefit.[9] Systemic Effects of Smoking: Cardiovascular system Nicotine stimulates the adrenal medulla to secrete adrenaline which stimulates the sympathetic system

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