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To increase the specificity of ABT263, the proteolysis-targeting chimera (PROTAC) platform was used for modification to generate three dual BCL-xL and BCL-2 inhibitors, PZ15227, 374 753b, 375 and WH244

Kennedy D, Samali A, Jger R (2015) Methods for studying ER stress and UPR markers in human cells

In 2016, 43.0% of the global adult population were current drinkers and caused 5.3% of all deaths ( Chronic heavy consumption of alcohol causes injuries in the organism, notably in the digestive, immune and central nervous system (CNS)

Proc Natl Acad Sci USA 85(12):45264529 Park YJ, Walls AC, Wang Z, Sauer MM, Li W, Tortoriic MA, Bosch B, DiMaio F, Veesler D (2019) Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors

Diabetologia 59 , 426435 (2016)