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In adolescents, smoking is associated with earlier menarche in girls and reduced sperm counts and motility in young boys

Prior to 1970, cigarettes manufactured for use in the United States used few additives, and there is evidence that the percentage of additives increased in the 1990s

Accounting for bias due to selective attrition

Bernstein and Oppenheimer both succumbed to smoking-related diseases, a fact that hangs over the two biopics but to which they never refer, although Maestro does portray a death from cancer in some detail

Currently, 14 patients have been enrolled in the study with recruitment ongoing