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Future work must also determine the downstream signaling pathway by which cell-autonomous HIF1a signaling acts to promote adult neurogenesis in response to IH

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One could therefore argue that outcome-relevant GPx3 optimization could not be achieved due to the dosing regimen of the SUSTAIN CSX trial: the first selenium dose was administered shortly prior to CPB and the inflammatory insult, leaving little time for selenoprotein biosynthesis and tissue protection