Trends in Food Science & Technology , 102, 5161
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Both GPX1 expression and activity were substantially lower in mice fed a selenium-deficient diet than those in mice fed a normal diet, leading to decreased trabecular number, reduced femoral trabecular volume/total bone volume ratio, and trabecular separation 66
The study builds off findings from previous work in Chandels lab, which found metformin lowers blood sugar by blocking a specific part of the cells energy-making machinery called mitochondrial complex I, a key enzyme in cellular respiration