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The resulting nuclear complex affects the transcription of estrogen-responsive genes, which is responsible for the production of various growth-promoting signals (Riggs and Hartmann, 2003)

Recent studies in mammals have further demonstrated that the gut microbiota can influence gonadal function through multiple mechanisms, including the regulation of circulating steroid hormones, insulin sensitivity, and immune homeostasis 185

Peptide-drug conjugates represent an emerging approach in cancer therapy

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