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The hydrophilic portion of the A42 peptide coordinately forms a bond with transition metal ions such as copper (II), resulting in abnormal yet stable neurotoxic aggregates of A [5]

10.18502/ijpa.v17i2.9542

We have preliminary evidence that transmission of pathology recapitulating abnormalities found in non-lesional MS NAWM occurs in humanized transgenic mice after intracerebral inoculation with MS brain homogenates (Tsutsui et al., 2019)