Unlike leucine and arginine, which directly bind to their respective sensors upstream of mTORC1 (Sestrin2 and CASTOR1), methionine is sensed indirectly through SAM (Gu et al., 2017)
In addition to promoting growth, glutamine has been reported to dose-dependently protect against inflammation-, endotoxin- and oxidant-induced cell death and damage in these IEC lines (114116)
However, the lack of human trials, quick degradability of liposomes and safety concerns of soy lecithin (a liposomal component) are barriers against its current use
Standard oral protocol: Dose: 500 mcg per capsule Frequency: Once daily Timing: On an empty stomach, 30 minutes before food Duration: 4 to 8 weeks Cycle recommendation: 2 months on, 2 months off Taking the capsule on an empty stomach maximizes absorption by reducing competition with food proteins for intestinal transport
Consuming with other supplements and food can help the absorption of those nutrients