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provided further evidence that HGF/c-MET signaling plays an important role in maintaining a central hallmark of cancer, the Warburg effect [105]

Induction of phase II detoxifying enzymes Many isothiocyanates are potent inducers of phase II detoxifying enzymes, including GSTs, UDP-glucuronosyl transferases (UGTs), NQO1, and glutamate cysteine ligase (GCL), that protect cells from DNA damage by carcinogens and reactive oxygen species (ROS) (25)

NF-B, Nuclear factor kappa-light-chain-enhancer of activated B cells

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