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10.1074/jbc.M700513200 J

Proposed Mechanisms Preventing GABA receptor downregulation Counteracting compensatory NMDA glutamate receptor sensitization Stabilizing benzodiazepine receptor configuration (preventing shift to inverse agonist state) Upregulating GABAergic neurotransmission through pathways distinct from benzodiazepine action itself This tolerance prevention has profound clinical implications

As a result, the healing process can feel less taxing, allowing patients to return to normal activities with greater ease

2022;5(5):e2213875

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