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American journal of physiology

There are several reasons why you might need a blood transfusion, including: Significant blood loss due to major surgery or a serious injury Bleeding in the digestive tract caused by an ulcer or other condition Illnesses like leukemia or kidney disease that cause anemia (low red blood cell count) Cancer treatments such as radiation or chemotherapy Blood disorders or severe liver problems For a blood transfusion to be safe and effective, the blood you receive must be compatible with your own blood type (A, B, AB, or O)