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FIGURE 2 3.5 Expression levels of pro-inflammatory genes in the kidney tissue As depicted in Figure 3, AFT could trigger renal inflammation indicated by considerable upregulation of mRNA expression levels of the pro-inflammatory cytokines (TNF-, IL-1, and IL-6) compared with controls

Reported concerns include local injection reactions, potential immunogenicity from copper exposure with chronic use, and theoretical risks if peptides activate unintended growth pathways

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