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ROS can oxidize proteins and cause DNA mutations, causing cell damage and cell aging, and excessive ROS will attack the protease complex on the oxidative respiratory chain, leading to mitochondrial dysfunction, reducing ATP production, inhibiting mTORC1, and promoting the differentiation of T cells into Treg cells (319, 320, 322), which is a vital cause of Treg cell functional deterioration

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Biochem Soc Trans (2011) 39:11026

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