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Basal OCR was decreased after 48 h, with no significant changes after 1 week of Taz -KD (Fig

Biochemistry 51 , 57055724 (2012)

In the obese trial cohort, 1 mg moved 24-hour heart rate by +0.7 bpm in the first week, essentially placebo. In a healthy lean Phase 1b group, the same dose raised heart rate by about 10 bpm, with a peak near 15 to 20 bpm around days 4 to 6. Lean, younger participants had more reactive heart-rate control than the sedentary, obese, and metabolically stressed trial population

But few know that it also has profound effects on receptors in the brain

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