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Increased lactate concentrations are also intriguing in the context of one of the influential hypotheses on the provenience of ME/CFS symptoms, a state of chronic, low-level neuroinflammation [61]

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Kadia T, Garcia-Manero G, Yilmaz M, Dinardo C, Konopleva M, Montalban-Bravo G, Borthakur G, Jabbour E, Jain N, Andreeff M , Short M, Issa G, Ohanian M, Bose P, Daver N, Wang S, Tidwell RS, Estrov Z, Ravandi F, Kantarjian H

In contrast, whereas about 45% of the patients in the placebo arm showed some improvement, only ~12% showed a 50% improvement