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By blocking TREK-1, PE-22-28: Increases neuronal excitability : Reduces potassium efflux, depolarizing neurons toward firing threshold Enhances serotonergic transmission : TREK-1 is expressed on serotonergic neurons in the dorsal raphe nucleus

Relative water content (RWC) is widely accepted as a reliable indicator of plant water status, as it effectively represents the equilibrium between water uptake and loss via transpiration 79

These three studies represent thousands of data points across performance horses and pathology, offering unparalleled insight into safety, efficacy, and long-term function

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Pathological Consequences of Glutamate Excitotoxicity In general, an excess or prolonged exposure of neurons and glia to high levels of extracellular glutamate during ischemia both lead to a massive Ca 2+ entry into the cells of both gray and white matter (Danysz and Parsons, 2003