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Both second-messenger events are required for maximal GH exocytosis, which is why activating only one pathway at a time leaves measurable secretory capacity unused

Patients with a history of medullary thyroid carcinoma, pancreatitis, or severe gastrointestinal disease should avoid these medications

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Theoharides, T.C., et al

Abbreviations GCLC: Glutamate cysteine ligase catalytic subunit GCLM: Glutamate cysteine ligase modifier subunit GSH: Reduced glutathione GSSG: Oxidized glutathione ROS: Reactive oxygen species C1q: Complement component 1q C3: Complement component 3 GSDMD: Gasdermin D GSDME: Gasdermin E DAM: Disease associated microglia DAA: Disease associated astrocyte Iba1: Ionized calcium-binding adapter molecule 1 GFAP: Glial fibrillary acidic protein NeuN: Neuronal nuclei HO1: Hemeoxygenase 1 CCL: CC Chemokine ligand CXCL: C-X-C motif ligand AD: Alzheimers disease App: Amyloid precursor protein A: Amyloid beta App : NL-G-F App knockin mouse NL-G-F References Guo, C., Sun, L., Chen, X