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However, it has to be emphasized that CNS inflammatory responses might be governed by different triggers than responses of the immune system on the periphery [12]
In the redox reaction catalyzed by glutathione peroxidase (GPX), GSH is converted to glutathione disulfide (GSSG), which can be reconverted to GSH by the enzyme glutathione reductase (GR)
Building on these findings, studies have shown that the active mitochondrial network in CRC cells exerts a physical metabolic occupancy effect that impedes immunological synapse formation, while the associated release of ROS further suppresses immune cell function
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