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10.1111/j.1471-4159.2009.06319.x 18 ChaiY.-C.MieyalJ

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Revisiting the cardiotoxic effect of chloroquine

In 8,124 patients with no established CVD or uncontrolled metabolic disease recruited in the URRAH study and followed for over 20 years, higher UA levels (defined at a cut-off of 4.7 mg/dL for all-cause mortality and 5.6 mg/dL for cardiovascular mortality) predicted all-cause [HR =1.25 (95% CI: 1.121.40)] and cardiovascular mortality [HR =1.31 (95% CI: 1.111.74)]

By influencing glutathione availability, glycine may affect oxidative-stress and detoxification pathways in cells