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Introduction Among 369 diseases analyzed across 204 countries, headache disorders ranked 14th in disability-adjusted life years (DALYs) for the general population and were positioned as the second leading cause of DALYs in females aged 1549 years (1)

Based on the obtained findings the maximum activity was coined with the 248A (identified in the molecular weight region 60 kDa to 70 kDa) and 248E (identified in the region 40kDa)

LL-37 is a potential mitigator of chronic inflammatory conditions in both male and female reproductive systems, experimentally applied to infections that cause persistent pelvic inflammation

These structures then fold and combine to form tertiary and quaternary structures, ultimately enabling specific biological functions 4,5,6

The specific profile of inflammatory mediators dominant in endometriosis (high IL-1, IL-6, IL-8, TNF-, CCL2/MCP-1, MMPs) shows a striking resemblance to the canonical components of the SASP secreted by senescent cells [57]