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Typically, involving healthy volunteers, these trials may include patients, particularly when investigating high-risk drug candidates such as certain antitumor drugs for individuals who cannot readily benefit from existing therapies

However, for patients who clearly have a severe intoxication, naloxone administration should not delay more definitive and evidence-based therapies (e.g., intubation and hemodialysis)

But one wrong move while making those twirls and twists can injure you

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Agilent Technologies, USA), a mixture of triethylamine-glacial acetic acid buffer solution (pH 3.5) and acetonitrile (87:12, v/v) served as mobile phase and the flow rate was fixed at 0.6 mL/min