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Accumulated protocol burden: More frequent administration can improve scheduling precision, but it also creates more opportunities for handling error

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The inotropic effect is augmented by caffeines inhibition of phosphodiesterase, which increases the concentration of cAMP in the myocardium and enhances the intracellular influx of calcium ions into cardiomyocytes

Cell Mol Life Sci 57 : 932942 Werner H, Shalita-Chesner M, Abramovitch S, Idelman G, Shaharabani-Gargir L, Glaser T (2000) Regulation of the insulin-like growth factor-I receptor gene by oncogenes and antioncogenes: implications in human cancer

This article breaks down what researchers actually know about it so far, what the data looks like, and why it keeps showing up in new studies