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Further regression analysis confirmed that smoking was a predictor of improvement in negative symptoms in male patients with SCZ (Beta = 0.26, t = 2.7, p = 0.008) (adjusted R 2 = 0.15)

We suggested that if self-medication explained the link between smoking and psychosis, then rates of smoking would be relatively normal when the illness first began and would only increase later on

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Effects of tobacco smoking on neuropsychological function in schizophrenia in comparison to other psychiatric disorders and non-psychiatric controls

Finally, the observational design precludes conclusions about causality, and we did not include longitudinal assessments in this analysis