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MES20 and GSC2907 GSCs incubated with or without Ox4 were treated with 5 Gy IR ( k ) or 200 M TMZ ( l ) for 1 h and lysed (n = 3)

1998;275:G749G757

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Employing melatonin as an immunomodulatory agent therefore may require higher dosages to be effective, for example in murine models, a dose of 10mg/kg is widely used to investigate the anti-inflammatory and tissue-protective actions of melatonin (70)