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The small second-order rate constant for the simulated reaction between GSH and the complex of reduced PfGrx C88S and roGFP2 WT (S 2 ) might reflect a poor accessibility of the 1st glutathione interaction site in this complex (Fig

J Surg Res 277:125-130, 2022

Iron, previously safely tucked away in ferritin and iron-sulfur clusters, spilled into the cytoplasm where it catalyzed the production of lipid hydroperoxides, triggering ferroptosisa type of iron-dependent cell death that is particularly devastating to therapy-resistant mesenchymal cancer cells

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