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Metabolic reprogramming driven by oncogenes allows cancer cells to maintain deregulated cell proliferation, withstand metabolic challenges that are associated with diminished oxygen and nutrients, maintain a dedifferentiated state through alterations in global patterns of gene expression, and corrupt the surrounding microenvironment to actively facilitate tumor growth and dissemination 16,17,18

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doi:10.1038/s41467-025-58680-y Carvas AO, Leuthardt A, Kulka P, et al

doi:10.1016/j.mam.2008.05.005