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NO is produced by the endothelial nitric oxide synthase (eNOS) and diffuses to the smooth muscle cells where it binds to the soluble guanylyl cyclase (sGC) that activates the cGMP-dependent protein kinase [63], leading to a reduction of intracellular calcium levels and thus to relaxation [53]

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Combining self-help materials with other strategies, such as medication or counseling, can enhance the chances of quitting successfully

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