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PMID: 5656589 Hibbs RE, Zambon AC (2011): Agents Acting at the Neuromuscular Junction and Autonomic Ganglia (Chapter 11)

Taken together, the combined burden of on-target toxicity and off-target effects constrains the therapeutic window and constitutes a practical barrier to clinical development, making it essential to pair analog optimization with delivery strategies that confine exposure to lesions and minimize unintended pathway engagement in normal tissues

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Furthermore, ferroptosis interacts with other forms of cell death, including apoptosis, autophagy, and pyroptosis, with growing evidence of crosstalk between these processes