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Chandy thinks the phenomenon occurs because the B12 allows the body to put itself right, and if you have had things wrong for a long time, then theres a lot to put right in a small period of time

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[60] However, these were the only positive effects from taking GH

Bacteria-derived hydroxocobalamin (OHCbl) and CNCbl are converted in humans to useful coenzyme forms to support metabolic processes such as mitochondrial methylmalonylcoenzyme A mutase conversion of methylmalonic acid (MMA) to succinate to link lipid and carbohydrate metabolism, and activation of methionine synthase, the rate limiting step in the synthesis of methionine

PMC 4953733