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This line derives from a cross between the Trkb- floxed ( Trkb lx ) line, as previously described 65 , and the BAC -Penk - cre tg/+ strain, carrying Cre recombinase under the control of the pre-pro-enkephalin promoter as previously described 13

However, the researchers did not observe the protective effect of CDDO-Im on the liver in Nrf2 knockout mice (Reisman et al., 2009)

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