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0.5 mg/0.1 ml saline/each eye) in rats immediately produced moderate generalized irregularity in the diameter of blood vessels with moderate atrophy of the optic disc and faint presentation of the choroidal blood vessels, and these lesions rapidly progressed to the severe stage

Because the pivotal trials studied the combination product, the isolated long-term profile of cagrilintide monotherapy in large populations is less fully characterized than the combination

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Tartar, D., Bhutani, T., Huynh, M., Berger, T