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Possibly the extended and vertical shape in MGST1 allows the conjugation of second substrate within the enzyme in contrast to MPGES1 where most of the substrate appears to remain outside the protein in the lipid bilayer (PDB IDs 4AL1, 4YL0, 5BQH, 5BQG, 5K0I)

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Oxid Med Cell Longev (2021) 2021:112