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Non-HDL cholesterol and LDL cholesterol both improved in the GLORY trials with mazdutide, and similar improvements are expected (though less specifically reported) with retatrutide

10.1038/ncomms11624 [DOI] [PMC free article] [PubMed] [Google Scholar] Koenig A, Buskiewicz-Koenig I

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Neither compound has completed the FDA approval process

Balancing Long-Term Safety, Cost, and Personal Goals Tirzepatide has been studied in humans for over a decade (previously tested in type 2 diabetes), and long-term safety data supports continuous use with standard monitoring