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For most water-soluble vitamins, such as vitamin C and B vitamins, the main concern with expired supplements is reduced effectiveness rather than harm

18 For the patient who presents with severe pain and acute onset of symptoms consistent with subdeltoid bursitis, the best treatment plan may be injection at the initial visit

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BCL-2 inhibition with ABT-199 shows efficacy in AML cell lines with synergistic effects upon addition of the MEK inhibitor GDC-0973 and prolongs survival in an NRAS/BCL2-mediated mouse model of AML post-MDS

Similar benefits appear in muscle injury, ligament repair, and bone fracture models